Dog_Bones ...
(a) one hopes that people don't operate the aircraft outside the envelope
(b) moving a few bodies from the back to the front or vice versa makes more than a moderate change to the total moment and loaded cg
(c) provided that the aircraft is kept within the approved limits there ought to be no handling considerations of any note ... apart from the tail scrape potential on the 734 if mishandled the two are pussycats ...
(d) the speed vs cg consideration is principally to do with tail trim drag ... minimising balance loads helps the beastie along ...
(e) only had a few hours in the DC3 .. but can't recall it being faster at forward cg ?