The most accurate simulation of the 744 at the moment, is the PMDG one. Comes with a failure menu, and the pmdg menu allows you to choose various customer specific options and so on.
Here two of my screenshots:
PMDG Simulations
In order to run it on mac, you will need to use XP/Vista/Win 7 over bootcamp (standard on OS X), FS9/FSX (FS9 being better if you dont have the most amazing machine)