Baltasound,
Interesting thread.
Fatigue and safety-critical systems are not the best bedfellows.
As a result of your post, I have just read Pringle's report on Hawes, (1910).
A different transport system, in a different era, (just after the events at Kitty-Hawk), BUT, There are still valuable teaching points here, almost 100 years on.
ATC has the 'luxury' of 3-dimensional 'avoiding-action'. Your options appear to be 1-dimensional. You folks can either stop it, or you can't.
Best Wishes and safe signalling.