I installed it on the desktop last week, and had no problems. I'd been running the Win 7 RC so knew what to expect from it.
The only difference that I see is that I no longer have the "Remote Desktop Server" on the desktop, which is a slight pain. I'll be looking for a suitable free VNC viewer to go on there, I think.
I'm in the middle of swapping the laptop to Win 7 HP now - or rather, the laptop is. I've just left it to get on with it.