Hmm, I suppose its the airflow towards the packs from the APU? I'm not really getting you I think
Can you specify the circumstances a bit more?
When the packs go offline for engine start it can only really get more quiet in the cabin... The isolation valve will open when any pack or engine bleed valve is closed, that might create a noise of sorts? (I'm talking 737-3/4/5 here, not sure about the NGs)