MAD-BIO
Possibly a good route but the route is already piled with seats. However, U2 would offer much better fares than IB would be able to so maybe a 2-3 times daily?
MXP-BIO
Would there be enough demand?
LGW-BIO
Maybe better for connections but the route would not be flying it is wasn't making money for U2 so obviously STN is popular enough.
GVA-BIO
Again, enough demand?