Ferry Flight to uSA
I have taken many singles across and in both directions. The one adage I have heard that applies the most is that your plane will make significantly more and different noises when you are over the water.
The regulations are not much different from the local ones in the EU or North America other than equipment requirements, but if you cannot go at 25,000 (FL250) or better, you need to fly far north or have an HF Radio for the leg between Goose Bay and Greenland.