I'd echo what AGB says. You'll have to synch your Ipod with a computer, so will have Itunes on that. It will be a lot more practicable to use that computer to drive your "zoned" system. You can get quite sophisticated with that.
I have a technofreak friend in the USA who has his house divided into sound (and lighting) zones. As he walks around, or goes up stairs, the lights come on for him and the music follows him. That's done with a transponder and remote in his pocket. He can also change what's playing from wherever he is.
I suspect, thought, that he paid something well over $10k for the lot.
I've done it much more cheaply in our cottage, using the Ipod as one of the input sources, with an amplifier in the lounge with two speaker outputs, and a "signal" line running round the house to separate main amplifiers and speakers. That only allows one programme. If M wants Radio 4 rather than my music, she uses a portable radio.