The short answer is no. Not with the 8 tonnes of contingency fuel a A330-200 needs to carry on that sector. You could not carry 300 passengers as well unless you were flying the higher gross weight A330.
You guys are missing the point. The reason a QF A330 will be flying that route is to get an international J class configured A330 on to the LAX-JFK run. The -400's flying that route now are not making any money. An A330 might.