Do you mean airline pilots will have difficulty is distinguishing the correct handles and levers without these visual queues? LOL!
No, but the more different from each other the various controls look
and feel, the fewer the chances are for the pilot to mix them up (and if the handles resemble what they actually control it's even more intuitive).
That's the lesson from past incidents, like people retracting the flaps immediately after rotation, leaving the L/G down instead (ideal for a stall), or a Super Puma's pilot engaging the nosewheel lock instead of the park brake, with subsequent rather messy taxiing.