Manx2 have got to be the only realistic hope for retaining a regular business focused NCL link.
Ofcourse BE also did NCL at one time, when they still had the smaller Dash-8's, the current ones are probably 60+ seats too many for a daily service. However when they get the 4th Q400, maybe a 3 or 4 times a week service, with sensible, leisure focused fares would work - like SOU, NQY or JER.