On the Bournemouth thread, there is a list of some 40 routes begun and ended since 1988 (21 years).
Here are my 40 odd, how many more have there been at Luton?
EasyJet: Liverpool, Jersey, Rimini, Bratislava, Zurich, Rijeka
Debonair: Newcastle, MGL, Munich, Barcelona, Rome, Perugia, Pontoise, Nice
Monarch: Malta
Britannia/Thomson: Belfast, Dubrovnik
Capital: Belfast City, Dublin, Leeds Bradford
Virgin: Dublin, Maastricht
Suckling: Amsterdam, Paris
BA: Paris, Isle of Man
Aer Arran: Isle of Man, Lorient
Air Turquoise: Vastry
Ciao Fly: ?
Helvetic: Zurich
Ryanair: Limoges, Skavsta, Dinard, Esbjerg, Rome, Cork, Waterford,
Eidelweiss: Zurich
European Air Express (?): Monchengladbach
BMA: Jersey, Guernsey
Victoria Air: Exeter, Manchester
London European: Amsterdam, Brussels
Netherlines: Amsterdam
(excludes destinations returned to, eg Ryanair Knock & Shannon, Monarch Palma, etc)