Most of us learned to fly on trainers with left hand on the yoke and right hand on the throttle. Some of us flew gliders with right hand on the stick and left hand on the spoilers. Some of us flew aerobatic machines with right hand on the stick and left hand on the throttle. Some of us spent time as a CPL flying single pilot with left on yoke and right on throttles. Some of us became FOs and flew for a period with right hand on the yoke and left hand on the power levers. I don't understand why people think there'd be a problem changing, you've probably changed at least once before in your career.