Point for the destination, notify ATC (such as it may be in that part of the world), and go in that direction, taking lower when able. Again, not rocket science.
...And run out of oxygen, letting many of the passengers DIE in the process or, in the event of an engine failure, drift gently into the terrain killing EVERYONE.
My ONLY job is flying aeroplanes, and I do so such that either a depressurisation or engine failure will not end my life or anyone elses.
You are fighting above your weight here Guppy- commercial operations over that sort of terrain REQUIRE stratergies to ensure saftey.
You assume that because it is outside you experience, it does not exist.
You are, quite simply, wrong.