It depends on how much thrust the engines produce.
Most twins will not keep flying if one engine fails and you can't feather it.
Commercial turboprops use an autofeather unit to protect life and limb on take-offs.
The only commercial twin I can think of that will fly on one with the other unfeathered is the Dash8Q400, so overpowered it's almost silly- but damn god fun as well, and only then with luck on your side.
It's just about the worst situation you can train for in any propellor aircraft and most simulators cannot replicate it fully simply because it's such a dangerous situation, flight testing would be crazy to try it in a real aircraft......