Yes, I think that doing a bit of practice on something like FS2000 gives some help in adjusting to instrument flying.
I think that if anything, it can give you a sense of what instruments and needles should be doing what at the right times.
The most beneficial practice I found was with NDB approaches. Add a wind, put the cloud down to 400’ or so, take off and practice intercepts, sector entries and approaches. I wouldn’t even bother with trying to hand fly it, just use the autopilot, the aim is to get used to scanning effectively and gaining situational awareness.