Why segregate them?....We have to grip the issue that they are here now and we have to deal with them. To reserve large chunks of airspace permanently is not doing the UAS/RPV/UAV community any favours in progressing.
Certainly restrict the types of RPAs into 'manned' airspace and or specify certain Sense and Avoid criteria (and if don't meet a particular standard and must fly, THEN segregate them).