The Air India 747 which was lost to terrorsm over the Atlantic in 1985 was carrying an engine in a pod.
I believe that in the early days of the Tristar, Eastern had an AOG at Mexico City (7,000 feet elevation), started a 2-engine ferry to Miami, and got a second engine failure on climbout. They got away with it, but I believe they never did one with a Tristar again out of Mexico. 411A will probably know the story.