844 Twotters built since 1966, probably an average 20,000 plus hours per airframe = 21,100,000 fleet hours, vast majority of hours on bush STOL operations.
As of August 2006, a total of 584 Twin Otter aircraft (all variants) remain in service worldwide. A number of Series 100/200 were scrapped due to reaching wing life limits. Series 400 back in production.
Would not consider that safety record unreasonable?
170 Nomads built. Wonder how many survive?