NEVER EVER TURN DOWN YOUR FIRST JOB!
One thing the ATPL's never teach you is that you must be prepared to operate from any base within the UK. What you must do though is talk with family and agree on a plan as to how you will cope and survive during the first few months.
In the current climate, you cant be too choosy. It will be hard and the level of homesickness will be high but it does get better, trust me.
Good luck and remember, its not forever.