I do think it's an important issue for pilots for the reasons stated-of course, public safety is paramount, but is it always justified to take away peoples careers in these circumstances.
We have to be careful about going down the route of relying on blood sugar measurements, we need to be looking at the outcome itself.
I'm not sure what a "near hypo" actually is, and I'm unsure if you can rely on a correlation between your wifes blood sugar and her symptoms.
As far as I can ascertain, metformin and/or diet control do not result in hypo's. I'm not sure if anyone has anything more scientific to rely upon other than my experience and the BNF.
Type I, of course, is a seperate issue.