Although I present myself to be shot down, I do believe that operating a 406 or similar aircraft safely can be more demanding than operating larger aircraft. Therefore some experience is at very least highly desirable.
Generally the larger the aircraft the easier it is for pilots to fly due to SOPS, support, only large airfields, established procedures etc. Small aircraft are operated from less controlled airports and environments with significantly more captaincy and airmanship required.
Fly safe
MM