It would be great except the weight and balance system on A330/A340 never worked properly, and I understand that nobody is flying it.
A GA pilot will know all the critical speeds to the nearest knot, it surprises me that an experienced crew would not 'intuitively' recognise the difference in V1, Vr, V2 speeds resulting from a 100 TONNE typo error when calculating the TO performance.
The speeds would have been out by double figures, and a good airman should have noticed.
That said a certain A330 operator had the mother of all tailstrikes when the PNF (a captain) scribbled down the VR, as 136 instead of 156, and the PF (another captain) dutifully rotated. They flew on and then managed to do a hard landing at the other end...