The parts about lack of differential pressurization between cockpit and main deck are common to all 747s (except the "guppies" flown by Evergreen, where the main cargo compt is unpressuruized) -- it can't be done.
Other than that, the question was specifically about the -400, so there's no conflict with any Classic info.
There are no relevant differences in Air Conditioning and Fire Protection between the straight 747-400F and the 2 different conversions that we fly.