Iceman:
No it is not possible nor practical and under what "regulatory" system would your "administrator" work.
You may think your ideas are workable but unfortunately you obviously have never worked in an airline / aircraft environment, details are never finalised until well after the aircrew have boarded!
OK, so what "can" we do? If we believe the rumor, one of the pilots typed a "2" instead of a "3" and nearly spread a 300-tonne mixture of passengers and kerosine all over the end of the runway.
The aircraft's computer could have spotted that one with its in-built sanity-checking algorithm, and issued a beep and a question such as "Is this aircraft empty? Then why so much fuel?"
Expecting the other pilot, apparently bleary-eyed from fatigue, to not suffer from dyslexia, was not so successful.
How about we get the ARRIVING crew to enter the estimated settings for the next flight before they leave the aircraft? The computer could then compare each of them with the real settings entered by the operating crew, and query any that seem so different as to be unlikely?
Just a thought...