It shouldnt really be a big deal as long as you brief for it..or at the very least have a plan.
Click..Click..get the automatics out (if you've got them) and do some proper aviating
I wonder what kind of separation are we talking about? is it 2.5 miles? and are we talking about differing types? i.e. A320 on a shortish final..and a ATR about to depart etc.