I think you have misread me.
Noise abatement is just one (low importance) consideration.
I was merely stating that just because you have 2000 feet or so of concrete/tarmac behind you on r/w 16 it does not make it any less safe than r/w 27 as there is still 8000 feet or so in front of you.
If I was trying to fly an aircraft at anywhere near MTOW, I would of course prefer the longest r/w available.
Thread drift in the prevaling wind.......
p.s. Have you never requested/done a takeoff with a slight tailwind in preference to a 3 mile taxi for a slight headwind ? All perfectly safe.