Hmm...
Well, MS Flight Sim 2002 has one, but it doesn't do anything like the real thing (power/pitch settings etc are way out), and it only has full rose on the EHSI or GPS nav, and no fmc/cdu.
However, there is an add-on you can buy which I haven't tried but am told gives you the full FMC and EHSI functions, and a realistic -400 flight model.
Can't recall what it's called (not much use here really), but I do know you can pick it up in PC world in the uk.