In all truth it'd be interesting to see what the actual payload of Conficker is. Are we going to see the world's largest botnet on April 1st? What will the botnets payload be? Spam? DDoS? Who knows....yet...
The biggest malware prevention is the user - keeping everything up to date, ensuring that adequate anti malware software is being run and not getting yourself into dodgy situations. The unfortunate thing is a lot of the time the typical home user will download anything and everything that they see, especially youngsters, without truly knowing what it is or knowing the consequences of what they are installing.
Conficker from my POV is a little strange, malware spread by exploiting a security vuln in Windows is far less prevalent than it used to be, owning to better patch installation/management and far better security systems. However, Conficker has also brought it home that there is still a LONG way to go on this front and that no 100% safe in the IT world.
I think at the minute it's a wait and see game, but take all the necessary precautions. Nowadays it's best to be one step ahead.