Is it not true that the effects of alcohol are more pronounced at higher altitudes? There's less oxygen in the air and thus in the bloodstream, therefore reducing the amount of oxygen reaching the brain in much the same way that alcohol does. That's why people suffering asphyxiation due to decompression (or whatever) usually act like they're drunk.
3 shots of vodka are usually enough to knock me out completely for a whole transatlantic flight. Judging by some of my own hangovers I would say a 36 hour "bottle to throttle" rule should apply. You're risking potentially thousands of lives in the plane and on the ground.
I'm surprised none of this has been mentioned yet. Then again one doesn't know where to begin disputing Old Lizzy's nonsense.