It would be interesting to see what these 46 pages consisted of with regard to the complexity and safety related issues raised....but we never will I suppose.
That said, as others have commented, every new type has teething troubles and I seem to recall the 767 had one or two..notably carrying some extra metal...or swarf if you prefer...that had been "missed" during the quality checks...... but not, subsequently, by the booster pumps. The toilets had a habit of failing with frequent monotony as well. All sorted out eventually as no doubt will be the issues with the A380.
However, the prize for the worst introduction to service must surely be held by that unadulterated heap of junk aka the ATP....so much so, that Waste of space held a series of "hearts and minds" ( plus BS! ) events to convince the operators the aircraft was as they claimed...even if the facts spoke otherwise.