I've taken off in a 747-400 from ORD 04L for LHR which is 2286m in length - no issues, can't remember if we derated thrust though, but I presume so.
Last week in SFO the take off runway was 19R (also 2286m) and we could just have made it (right at RTOW, within 100kg or so), but 19 at SFO has terrain concerns so we opted for 28 (again for LHR). OK so we were relatively light, prob about 330t, but nonetheless, it would suggest that BRS is not a big problem especially for landing, yet will concentrate the minds.
PS Have landed at BOM at about 270t (MLW 285t) and vacated at W from 27 which is about 1700 metres without hammering the brakes (WIP meant otherwise full length and backtrack).
HTH