From experience (flew RHS quite a bit with a mate of mine in his a/c), no big deal. Just takes a bit getting used to doing things with your hands 'the other way round' and, of course, the slant angle to the instruments, assuming you're flying a 'pilot-side instruments only' spamcan. The only one I found tricky there was the AH/AI in marginal VMC. I'd go up with an instructor or other pilot first. If alone, check you can actually reach ALL switches before taking off - might come in handy
