According to ICAO and JAA with an atpl licence and 1500 hours including Jar/far 25 (jet or Turboprop) you can be a commander of an A380, a350, a340, a330, a320, a310, a300, b747,b767, md11, etc, etc, etc....
If it was unsafe, they would change the rule!!
The Captains I flew with in the TP world had a blatant disregard for the MEL, FTLs, the QRH, aircraft limitations, the Ops Manual....the list goes on.......
Can you explain a bit more, because I don't see the relationship