Hello flyby
We take the lowest MAC stated on the loadsheet, mostly being the MACTOW, and subtract 5% for the CRZ CG. This is not on the CL, though. That's the NG.
And that's conservative for our type of operation since we most often have fuel in the centre tanks, and burning away this only increases the MAC CRZ CG.
This would be the opposite of what you're theoreticizing, since this gives us more than actual load margin on the speedtapes.
The positive moment and minimum speed you experience during initial cleanup in climb, usually V2+15, and the negative moment you experience during speed buildup in climb are both accounted for by inserting the MACTOW before departure.