not in the way that works in Boeing/Douglas/Tu-134
Did you know Boeing is asking around if anybody wants a true 200-260 seat replacement for short / medium haul ?
Boeing 737/757 RS Pitches Larger Light Twin Civil Aviation Forum | Airliners.net
probably the gab between 737-900 / A321 and the twin aisles a330/350/787 can't be rationalized away from real market demand.
Bulks of 757, A300/ A310/ 767-200s ,Tu 154s flying around for which a big twin replacement just ain't realistic.
Good news is Pratt seems to dimension their new geared fan engine upwards to 40.000 lbs, which should be sufficient for such an aircraft, e.g. a Airbus A325..
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icture : A346 GTF flight test crew via Flightblogger