If operating in remote places a hidden benefit of four engines is you could always ferry fly on 3 engines to a maintenance facility...
But as with every type there are always quirks and little niggles here and there as well as benefits that out weigh them.....
As some operators are going to the wall this may reduce the demand and price of spares, but it is an orphan (no longer in production) so as time ticks by spares may become harder to source.....
If remote places are being used as mentioned the 146 is good for rough and short runways/ steep approach's so really it depends on where the a/c will be used as to if the it is more viable than a 737