Having just recently bought a case with one of these security nightmares fitted, the first move was to fill the keyhole with epoxy resin
Prepare to have your locks broken open by the TSA then!
My bags don't have built-in locks but have a point where you can insert your choice of padlock so I use a TSA-lock when travelling by air. I can see the point of having locks without a backdoor for non-airline travel, however if you have locks on your bags with no backdoor for them, the TSA may well break them, and then your bags won't be locked against any other thieves (or even just to hold them closed!).
This state of affairs does not make me happy, but until I have my personal aircraft to take me around the world, I'm stuck with it. I just complain every time I see a deviation from procedure so that they get some hassle.