1/ Take you car to a good mechanic a few weeks before heading off.
2/ Carry crap loads of water including enough for an entire cooling system refill.
3/ Zip down to supercrap get a 10 buck puncture repair kit and a 20 buck aircompressor and know how to use it. $30 is cheap insurance when you hit an old bolt at 100 clicks. doing highway driving you are more likely to get a tread puncture than sidewall.
4/ It has been said before but I'll carry on... DO NOT TRAVEL AT NIGHT!
5/ Take the extra day and enjoy the scenery.