I've got 2hrs ME in my logbook and it was in a 421C and it was the slickest plane I have ever been in.
Speaking personally, I would examine the "mission profile" (I know certain people on here hate that phrase) carefully, because it does burn avgas, lots of it, and a SE turboprop is worth a look at for the widely available fuel. However, a SE TP will cost more to buy than a 421C, I am sure.