KBOS: I'd say the major things to watch out for in this airport are runway infringements and crossing arrivals/departures.
There is normally a mix of heavy/medium/light traffic taking off and landing on several different runways. Last time I was there they had split frequencies for the tower, so you could have aircraft operating off intersecting runways without knowledge of each other.
Being in a triangular pattern, there are many places where runways cross other runways and/or taxiways. In poor vis. it can be quite a job to figure out where you are in relation to all these, especially in the area where 27 and 22L/R meet. This is in addition to coping with the normal machine-gun fire RT from tower and ground. Before you land I'd study the taxi charts carefully and have in mind the sort of clearance you might get and where the critical holding points are. It might even be useful to photocopy the chart and magnify it a bit in the process.
If the cross/tailwind is strong enough
you might get given RW27. Although the LDA begins with a "2", you don't want to end up in the mess of taxiways/runways near the end of it. Not a good RW for a long float or low autobrake in a "heavy", IMHO.
When leaving, keep a keen eye out for other traffic, as I have noticed a tendency to be cleared for TO earlier and earlier, sometimes when the offending aircraft has yet to cross the RW you are using.
Not a place to be "heads down" too much as there is a lot going on out there.
OTOH, a great city with a more "European" flavour than many in the USA. Lots to do and appears to be pretty safe these days. Enjoy.