I think I'm correct in saying that if the program requires you to point to the location of the scenery files at install then you need to be certain that the drive path remains the same. If you have other removable media then depending upon the configuration at the time the "D" drive may become the "E" drive........ I stand to be corrected on that though!
Edit to say - I just thought if your D drive now contained the memory stick that you have all your porn stored on then you may prefer the look of those pink valleys hehe!