... not unless...
No, you won't suffer any probs to you running programs. However, there is the odd occasion when - say - MS Office gets corrupted. (Had that happen a time or three: something to do with my trying to fix summat that wasn't broken, probably.) At that time, you will get the Office God suggesting you might like to repair...or you might make that decision for yourself.
At that point, it's great to watch Windoze look for, find, and reinstall your software for you. Saves finding the cd, fighting the machine for the right place to look - you probably have done this from time to time, & know that sometimes it's a bit frustrating.
But ok, your choice!
Jim