The winglet equiped NG will have better fuel consumption during cruise.
The longer the flight the less (about 3%) it burns compared to the non equiped.
Personally I find the NG with winglets to be more demanding on crosswind landings. Friends that flown the non winglet NG say that it behaves better especially during gusts.
As far as flare is concerned due to the thin-long wing the a/c tends to continue fly. An added factor to that is the high approach speed especially on Flaps 30!