If my memory is correct after 30 years I recall that the B707 used to have a performance decrement applied in strong crosswinds (15 kts + I think) which was to compensate for the spoiler drag.
On the modern FBW Airbus`s the technique is to centralise the ailerons at the point of rotation and indeed to avoid using excessive aileron into wind ie. enough to raise the spoilers, by restricting the sidestick input by use of the `cross` to a value where the spoilers are not deployed.