That's the classic configuration for a purpose-built freighter. Ben Howard of DGA fame designed a small twin about 1939 with high wing, ramp-loading tail, called it DGA-10. Never built, unfortunately, but it had plenty of follow-ons by
Curtiss,
Budd, Fairchild, Lockheed, DHC & McD-D - plus the Argosy and Transall in Europe - and the Il-76 and Antonovs etc etc.