Porrohman
Yes. I did one. I think the load was about 50-60 pax outbound from GLA-SFB but we were full back (180 pax/ 2 class config.) & made it both ways non-stop with no problems.
I flew a few B757 Trans Atlantic trips with AMM/FCA & while virtually all westbound flights tech stopped in Bangor, Maine, you needed a certain set of criteria to enable a non-stop return sector. At the pre flight planning stage in MCO/SFB as a rule of thumb you needed a ZFM of around 78 Tonnes & a 25kt tailwind component.
GSM's 757 even when full is around 75 Tonnes ZFM so needs a lower tailwind component in order to make the eastbound sector non-stop.
It's a remarkably versatile machine that a B738 or-9 could never match.