Having flown the Md-80/Dc-9 series in the past I've experienced thrust reverser deployment just after rotation in the sim. While the aircraft yaw is controllable the reverse thrust and added drag of the deployed buckets over came the thrust of the 'good' engine causing an uncontrollable descent rate. Only way to survive was to immediately shut down the engine with the deployed reverser.
I found the old clam shell buckets to be much more effective than a sleeve type ( flew the 737 -200 and 3/400 series as well).
I believe an inflight reverser deployment caused the loss on an Air Lauda 767 some years ago.