Depressurisation requires immediate descent to Lsalt and sucks fuel and so requires an immediate landing. Never mind the wx, the tower will clear the runway for your emergency, hence no holding.
Wait a minute. Not a descent to LSALT, rather FL130 where supplemental O2 is no longer reqd for pax. LSALT over the sea (1500 MSL) or even one of 5000 MSL over some mountains is still going to burn far too much fuel. It's FL130 not LSALT (in fact it's really HSALT when you think of it). And it does NOT require an immediate landing, just a planned landing before you burn into your reserves. Save immediate landings life threatening situations like fire not just decreased performance because as Meatloaf said "Two out of three aint bad"
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Secondly DO mind the wx. ATC will clear the traffic and the runway but not the CB pissing hale/lightning/brimstone on the threshold... and the 727 handbook says to.
FRQ CB