At the end of the day, crews are highly trained for these situations
Yes - they may have received simulator training and had all the boxes ticked BUT we all know some pilots who in reality would never cope if forced to conduct an emergency descent with one pilot incapacitated. Usually these characters are known slackers but have been in the game for a few years and still lack the drive for excellence. As loss of consciousness by one of the two cockpit crew during the immediate aftermath of a rapid depressurisation is a significant possibility, perhaps simulator training should include training for that event - ie single pilot operation emergency descent. That would sort out the competent from the incompetent in such a serious situation.